Shouldn't testosterone replacement therapy be an easy concept to swallow?
Say hello to oral delivery with JATENZO.
MEET THE FIRST ORAL SOFTGEL Testosterone Replacement Therapy (TRT) That Offers Dosing Options1,2
JATENZO is an oral formulation of testosterone undecanoate that is formulated as a lipophilic testosterone prodrug1,3
It's absorbed via the intestinal lymphatic system, therefore avoiding first-pass hepatic metabolism1,3
In clinical trials, no liver toxicity-related events were observed1,3
Mode of Absorption1,3-5
JATENZO's intentional design enables safe oral delivery of testosterone undecanoate, which is delivered almost exclusively (>97%) via the intestinal lymphatic system.
Click through the steps below to learn more.
Taken orally with food
Each JATENZO softgel contains testosterone undecanoate (TU), a prodrug formed by attaching a fatty acid to testosterone, which the body naturally cleaves off to release testosterone.
Carried by lipoproteins into lymphatics
Once in the intestine, this lipophilic prodrug combines with lipoprotein particles, allowing absorption into the intestinal lymphatic system. In contrast, carbohydrates and proteins are absorbed into the portal circulation.
Avoids first-pass hepatic metabolism
JATENZO passes into the intestinal lymphatic system (therefore bypassing the liver) as testosterone awaits activation.
Release of active testosterone in circulation
After TU releases from lipoprotein particle, endogenous esterases liberate testosterone from TU. Fatty acid is metabolized like dietary fatty acids.
Lipoprotein particle
Proteins and carbohydrates
TU prodrug
Active testosterone
TRT Administration shouldn't be much of a challenge6,7:
Oral delivery offers:
No injection pain, no procedures
No mess, no drying time
No transference concerns
No skin irritation
No gum irritation/disorders
No nasal irritation